Noroviruses are responsible for the majority of gastroenteritis in developed countries and can trigger acute outbreaks in hospitals and nursing homes. However, there is no vaccine and no specific therapy. Therefore, the PRESENt partners from TWINCORE, the Hannover Medical School, the L3S Research Institute of Leibniz University Hannover and the Helmholtz Centre for Infection Research are pooling their expertise at the newly established Centre for Individualised Infection Medicine (CiiM) in Hannover. The PRESENt consortium will use data-intensive technologies and machine learning methods to develop strategies for personalized prognosis, prevention and treatment of severe norovirus infections.